I am currently 6w5d pregnant, which is the farthest Ive been. PGS Testing Risks - CNY Fertility After each failed transfer, my RE did a lot of additional testing including a Yale EFT biopsy for receptivity and a clotting test to see if I needed lovenox and/or baby aspirin. Im sorry that didnt work. The chances of having a positive outcome with PGS testing and IVF depend on the number of the produced embryos that have a positive result in the test. Miscarriage is defined as a loss between clinical pregnancy (detection of a gestational sac or heartbeat) and 20 weeks of gestation. I miscarried a genetically normal baby girl at 8.5 weeks and they tested me for autoimmune disorders so that could be something to check for as well. no, I just took those 3. I also had a chemical with a PGS tested embryo. I remember you from another post I made about only having 2 eggs fertilized you were so kind to share your story. PGT-A (formerly PGS testing) is a technique that determines the number of chromosomes in the cells of an embryo. Second, PGS speeds up the time to pregnancy. My first FET was a day 6 5AA euploid embryo. According to the geneticist, there is as much chance it could be completely normal as the chance that it is abnormal. Dear ALL0130, thank you so much for your reply and encouragement! Thanks for sharing! I've read that in a non-IVF pregnancy, the rate of miscarriage is about 21.3% between weeks 5 and 6. Success rates with chromosomally normal embryos, complete guide to embryo grading and success rates, https://www.remembryo.com/pgs-success-rates/#Embryo_grades_and_PGS_success_rates, They also found that the chance of getting a complex abnormal embryo increased with age, Graded as excellent (AA) or good (AB or BA) = 50% live birth, Graded as excellent: 84%ongoing pregnancy, 0% miscarriage, Good: 62%ongoing pregnancy, 3% miscarriage, Poor: 36%ongoing pregnancy, 19% miscarriage, Thaw the embryo and culture it until it can be biopsied (this may take a few hours to a day), If the 2nd test comes back euploid and you transfer, another thaw will need to be done. Best of luck on your next FET! Tiegs (2020) in their multicenter prospective study transferred 414 blastocysts that were only tested using PGT-A after the pregnancy outcome.So no one knew what was being transferred. This ended up working for me after my biochemical pregnancy. I just received news today that out of our 14 blastocysts only 4 passed pgs and 1 with no result that we are retesting. I'm glad we did - because my ERA results were abnormal and I needed 12 more hours of PIO. LBR was associated with morphologic parameters of euploid blastocysts, especially in women <30 years old. Nov 2, 2016 8:12 AM. Out of the 6 that were pgs tested, 3 came back normal and 1 came back inconclusive. This is my second failure of a PGS tested embryo, and the first on this immune suppressing protocol. Im very sorry and hope you can find the strength to continue. After a chemical with 2 PGS normals and two miscarriages around 8 weeks (spontaneous pregnancies) and another failed transfer, I found out I had an infection in my lining that can only be detected by a biopsy. In the past PGS was seen as the holy grail - if the chromosomes are normal we should have implantation and a normal pregnancy. Turns out I was 24 hours prereceptive and Im convinced the ERA and extra day of progesterone is what did it. wow, Im so glad you were able to get a second opinion. After that we decided to just go straight to IVF given the chance of successful pregnancy with IUI was very low. My husbands sperm analysis was only very slightly abnormal. For the successful ivf only ONE healthy embryo is enough. hang in there. I guess I'm facing wasting the investments of stimulation vs potentially wasting the investments in proceeding but also getting more information that might help with future cycles. Did your RE have you take anything other than progesterone and estrogen and aspirin? Youre right! Learn more about, Learn About What to Expect's Pregnancy & Baby App. There isnt much data on it, and 2 of the 3 studies found no difference, so it isnt exactly clear. Did you do anything different with your FET? We are currently looking to use a gestational surrogate in Texas. Normally, we have 23 pairs of chromosomes (or 46 in total) one pair comes from the egg from our biological mother, and the other comes from the sperm from our biological father. I went into my second egg retrieval and got less eggs than the first time around. I only have embryo left ugh . Does PGT-A reduce the chances of miscarriage? Thanks! We have one (and only one) 4bb PGS normal embryo. It's my second transfer. No additional testing has been offered after 3 chemicals and one failed implantation on PGS normal embryos - he just tries to push me onto surrogacy each time saying sometimes thats the only option. in reply to 3 years ago Thank you so much! My questions is only 28% of our blastocysts passed pgs testing which is quite low from what is predicted for those under 35. I just wish we had more answers so we can prepare for the next . Check here for the full glossary (please excuse the repeated terms!). My first FET was a day 6 5AA euploid embryo. This was something that almost all of our embryos had problems with (a high drop off rate of embryos growing in the lab and all were always low rated if they made it to blastocyst stage). (The embryo split!) I also want to add low dose prednisone and lovenox - I have heard from so many of you that even IF no autoimmune issues are found that this combo helps. Group Black's collective includes Essence, The Shade Room and Naturally Curly. Group Black's collective includes Essence, The Shade Room and Naturally Curly. Did you get your BFP on IVF post the antibiotics or naturally? Preimplantation Genetic Testing - RSC Bay Area That sounds a lot like my dr. Its basically an assembly line in there. RPL and endomitritis biopsy isnt a new thing, and its the same procedure as an ERA (which I also highly recommend). Some background on us: diagnosed with severe male factor IF 4 years ago, did one round of IVF/ICSI which resulted it a chemical pregnancy. While those are great odds, sometimes the FET fails. It kind of makes me wonder what they get out of their alternative recommendations. I hope this gives you some hope. Tiegs (2020) in their multicenter prospective study transferred 414 blastocysts that were only tested using PGT-A after the pregnancy outcome. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. Lack of common pregnancy symptoms like morning sickness or breast soreness after a positive pregnancy test. I also went for a lot of second opinionsall of the drs said there were many reasons and theories for why pgs embryos fail but its not uncommon. We did do some things differently, however my RE did these things more to appease me because he knew how frustrated I was than because he thought they were medically necessary. Can you tell me the success rate? The psychologist who ran the group, who also happened to be an RE at my fertility clinic, explained that sometimes you have a seemingly perfect embryo, perfect uterine lining, and the FET just fails. I am hoping number 5 is it. Good luck to you on this journey and I hope round 2 is successful for you!! Is there any reasoning behind this- is it due to poor egg quality, poor sperm quality, or both? Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. I dont know if this is helpful or not but Ive had 4 FETs. For more up-to-date information on this topic check out my other posts that are tagged withPGS (PGT-A) success rates. I took the year off to just work on myself and be in a better mental state. However we now understand that the chromosomes are only part of the issue. He earned his MSc in 2012 for his research on inflammation and lung cancerand started Remembryo in 2018 to help people understand the evidence behind common IVF topics. I will talk to my dr about all of the above and hopefully i can finally get some answers :) My dr keeps pinning it on my lining but it doesnt make sense to me since Ive been over 8mm with a triple line pattern each chemical. Im still taking it! A recent 2019 study looked at 130,000 biopsies by NGS tested (this is the current testing method): Demko et al. Aneuploids on the other hand, at least based on 1 study, seem to have a 100% miscarriage rate. Im hoping to do another transfer in January. This study is considered the best quality evidence currently available for PGT-A (which showed no benefit over traditional grading for women <35 that you read about that here). Im sure that data exists especially since thats how things used to be done back in the day. After 10 days, they came back and said that it was low and that i should mentally prepare myself for a chemical pregnancy. So most <35 women are between 30-90% chance ofeuploid(61% is the average). If you haven't had multiple losses/failed attempts feel free to comment but please be empathetic when doing so. Reply Share React AMB425 Sep 2, 2016 11:01 AM He provides weekly summaries of the latest IVF research and posts on Facebook, Instagram and TikTok regularly. thats a great suggestion! Did you ever go through with your day 7 FET? However, these differences were not found in women older than 30 years. Please can you offer a perspective? He also answers questions in his private Facebook group. my first 2 cycles were artificial but my last 2 were natural and unfortunately no luck :( Hopefully we can get somewhere with the ERA. MENTS my 3rd FET was a success end MENTS. I know this is an incredibly hard time and it's a tough decision- best of luck to you- don't give up hope. Chemical pregnancy with PGS tested embryo. He provides weekly summaries of the latest IVF research and posts on Facebook, Instagram and TikTok regularly. I just found out today that I've only got 2 larger follicles and 3 smaller ones that are growing but are quite behind the 2 larger ones. They also reported the number ofblastsbiopsied. Use of this site is subject to our terms of use and privacy policy. If you did PGS after multiple miscarriages and failed attempts how many did you transfer? I had biopsies after a polyp removal which showed residual B cells (even after 3 rounds of antibiotics), my RE didn't think much of it. I was completely devastated because I never thought that would happen with a PGS. Obviously, when we look at transfer rates with PGS tested embryos, we are not including all the women who didnt have anything to transfer. How does anyone not go completely crazy through this whole process???? We are at a loss as both embryos transferred (one late last year and one last month) were PGS normal. Im willing to try anything :) thanks for sharing! Generally, Day 5 embryos perform better than Day 7 embryos. Hi, i didnt have chemicals, I had bfn for my first two transfers. You can check out my summary of the study here. frustration and tears were worth it.